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Such a model could prove useful in investigating how the interactions between the above factors may contribute to the pathogenesis of ASD, and identify potential biomarkers that could be used in early detection and screening for this disorder. Our research group has been developing a novel rodent model of autism to examine enteric bacterial metabolites as possible environmental triggers in ASD.
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Several recent studies have indicated that interactions between genetic, metabolic, immunological, gastrointestinal, environmental, and behavioral factors may be associated with the pathogenesis of ASD. These alterations suggest that the propionic acid rat model is a useful tool to study aberrations in lipid metabolism known to affect membrane fluidity, peroxisomal function, gap junction coupling capacity, signaling, and neuroinflammation, all of which may be associated with the pathogenesis of ASD.Īutism spectrum disorders (ASD) are a family of disorders characterized by stereotypic and restrictive patterns of behavior, deficits in social interactions, and impairments in language development and communication skills.
#Thebrain 9 thought checkbox Pc#
Notable alterations were observed in the composition of brain SM, diacyl mono and polyunsaturated PC, PI, PS, PE, and plasmalogen PC and PE molecular species. Lipid analysis revealed treatment altered 21 brain and 30 blood phospholipid molecular species. Propionic acid infusions increased locomotor activity. Animals were infused daily for 8 days, locomotor activity assessed, and animals killed during the induced behaviors. We applied ESI/MS to determine how brain and blood intact phospholipid species were altered during the induction of ASD-like behaviors in rats following intraventricular infusions with the enteric bacterial metabolite propionic acid. A paucity of information exists on how the intact phospholipid molecular species are altered in ASD. Most of the phospholipid analyses have been conducted on the fatty acid composition of isolated phospholipid classes following hydrolysis. Gastrointestinal symptoms and altered blood phospholipid profiles have been reported in patients with autism spectrum disorders (ASD).